All posts in Medical Ozone Against Ischemic-reperfusion Injury

Medical Ozone Ischemic Injury

Medical ozone ischemic injury

Medical Ozone Ischemic Injury

Ischemic and ozone oxidative preconditioning in the protection against hepatic ischemic-reperfusion injury

Hussam Hassan Ajamieh1, Silvia Menéndez2, Nelson Merino1, Susana Sam1, Olga Sonia León1*
1Center of Research and Biological Evaluations. Food Pharmacy Institute. Havana University.
2Ozone Research Center. POBox 6880. Havana City. Cuba.

 Abstract

It  has  been  demonstrated  that  ozone,  probably  by  means  of  an  oxidative preconditioning (OP) mechanism, protected the liver against the damage mediated by reactive oxygen species. Taking into account that ischemic preconditioning (IschP)  is  also  a  protective  mechanism,  a  comparative  study  between  both preconditioning effects, with the aim to study the effectiveness of both protective procedures, was performed. Rats were divided at random in: 1- control, sham operated (anesthesia and laparotomy plus surgical manipulation); 2- I/R (ischemia for  90 min followed by 90 min reperfusion);  3- IschP  + I/R, as group  2 but submitted  to  a  previous  ischemic  preconditioning (ischemia 10  min  and reperfusion 10 min); 4- OzoneOP + I/R, as group 2 but submitted to a previous oxidative  preconditioning  with 15  sessions,  daily,  of  ozone  by  rectal administration (dose = 1 mg/kg). The comparison between both preconditionings showed no biochemical differences for the parameters evaluated. Nevertheless, the histological study demonstrated that the protective effect produced by the OzoneOP is superior to that achieved with the IschP.

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