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Ozonated Saline Use

Ozonated Saline Use

Intravenous infusion of ozonated physiological saline

The priority of the Russian school of ozone therapy is the wide use of intravenous drop-by-drop infusions of ozonated physiological saline – a simple and effective method of parenteral exposure of medical ozone.

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It is important to note that this method allows to receive positive therapeutic effects in different medical problems by using considerably lower, i.e. more safe ozone concentrations compared with ozone concentrations accepted by the European school of ozone therapy.

Fig 1. 

Description of the Method

Ozonated physiological saline is produced by conveying ozone-oxygen mixture through a standard bottle with 200 or 400 ml of sterile physiological 0,9% sodium chlorid solution to saturation and then infused intravenously to the patient (Fig. 1).

This procedure can be performed in two variations – after interrupting bubbling with ozone for the time of intravenous infusion of solution (Fig. 2) and by infusing solution during continual bubbling with ozone (Fig. 3). Mark of zero on the axis shows the beginning point of intravenous infusion of ozonated saline.

  Fig. 2. Change in the amount of dissolved ozone during infusion of ozonated physiological saline after interrupting bubbling with ozone.  Fig. 3. Change in the amount of dissolved ozone during infusion of ozonated physiological saline by continual bubbling with ozone.

In both the cases, before infusion saline should be previously bubbled with ozone to saturation (saturation – mark of 100% of dissolved ozone, see Fig. 2, 3). Saturation of solution with ozone concentration in gas mixture 400 – 2000 mcg/L can be achieved for 10-15 min at flow rate 1 L/min and for 15-20 at flow rate 0,5 L/min. Further bubbling results in an insignificant increase in the amount of ozone dissolved in the physiological saline (formation of additional active species of oxygen) that can be disregarded.

Calculation of the Dose

Considering that the concentration of ozone dissolved in the physiological saline is approx. 20% of the given ozone concentration in gas mixture i.e. dissolution coefficient is 0,2, that means that for example at ozone concentration in gas mixture 1000 mcg/L in 1 L of physiological saline the following amount of ozone will be dissolved: 0,2 x 1000 = 200 mcg O3 (calculation error not more than 10%).

In case of infusing an ozonated physiological saline by continuous bubbling, saturation of saline remains practically constant all the time of procedure (Fig. 3, area II). The dose of ozone infused to the patient is calculated as follows:

Dose (mcg) = 0,2 x concentration O3 (mcg/L) x volume of saline (L)

For example, at ozone concentration in gas mixture 1500 mcg/L and volume of saline bubbled with ozone 400 ml the dose of ozone infused the patient during the procedure = 0,2 x 1500 x 0,4 = 120 mcg O3. During the procedure after interrupring bubbling with ozone for the time of intravenous infusion of ozone it is important to know that decomposition of ozone after stopping bubbling is described by complex exponential function, the half-life of ozone is approx. 30 minutes (Fig. 2, area II). The total dose of ozone infused to the patient within treatment time of 30 min is 67% of the dose calculated for the procedure by continuous bubbling (calculation error not more than 10%):

Dose (mcg) = 0,67 x 0,2 x concentration O3 (mcg/L) x volume of saline (L)

For example, at ozone concentration in gas mixture 1500 mcg/L and volume of saline bubbled with ozone the dose of ozone infused to the patient during the procedure = 0,67 x 0,2 x 1500 x 0,4 = 80,4 mcg/ O3.

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