All posts by ozoneresearch

Medical Ozone Endometritis

Medical Ozone Endometritis

Medical Ozone Endometritis

The Treatment of Endometritis in Combination with Ozone therapy

Guennadi O. Gretchkanev1, Tatyana S. Katchalina2, Olga V. Katchalina3, N.N. Saifieva4,
El-Hassoun Husein5
1,2,3,4 Department of Obstetrics and Gynecology, Medical Academy of Nizhny Novgorod,
Pl. Minina 10/1, 603005 Nizhny Novgorod, Russia
5 Russian Association of Ozone Therapy, Jordan

Abstract

The inflammatory diseases of female genital organs are numbered among the most frequent pathologies of fertile women. In order to increase the efficiency of  treatment and to avoid possible side effects we have used intrauterine irrigations with ozonated distilled water in case of  acute  endometritis. This method of treatment  has  been  provided  to 15  patients  with  postnatal  and  post-abortive endometritis. Based on the received results, we have drawn a conclusion that in the course of treatment all patients showed an improvement in general state, body temperature returned to normal, symptoms of intoxication decreased, sleep and appetite got better, pain syndrome disappeared faster, pathological discharges were eliminated. The results of laboratory investigations have demonstrated a credible decrease in ESR, normalization of leukocyte number, a decrease in circulating immune complexes.

Thus, for treatment of endometritis we may recommend the given method of ozone therapy to be used in combination with a basic anti-inflammatory therapy.

Introduction

Endometritis is being still numbered among the most frequent pathologies of fertile women. But  in  spite  of  considerable  success  achieved  in  the  treatment  of  inflammatory,  incl. gynecological diseases, the problem of efficient treatment of endometritis is not solved yet. It can be explained as follows:

  1. high frequency  of  complications  due  to  endometrial  manipulations (therapeutic abortion, diagnostic endometrectomy and so on) that mostly appear then in the form of acute endometritis;
  1. considerable risk that the infectious-inflammatory process localized in uterus will generalize;
  2. numerous side effects of medicines to be used within the traditional treatment of endometritis.

In practical gynecology along with a basic therapy (antibacterial, desensitization, vitamins, sedative remedies) antiseptic preparations have been widely used in the form of intrauterine applications. The aim of this manipulation is to improve the removal of pyo-necrotic masses as well as to produce a medicinal effect directly in the focus of inflammation that however
can cause a number of side effects.

Read full document Medical Ozone Endometritis here.

Share Button
More

Medical Ozone Ovarian Cancer

Ozone therapy ovarian cancer

Medical Ozone Ovarian Cancer

Medical Ozone for Prophylaxis and Treatment of  Complications
associated  by Chemotherapy of Ovarian Cancer

Guennadi O. Gretchkanev1, Tatyana S. Katchalina2, E.Yu. Palkina3, Claudia N.
Kontorchikova4, El-Hassoun Husein5
1,2,3 Department of Obstetrics and Gynecology, Medical Academy of Nizhny Novgorod,
Pl. Minina 10/1, 603005 Nizhny Novgorod, Russia
4 Central Research Laboratory, Medical Academy of Nizhny Novgorod,
Pl. Minina 10/1, 603005 Nizhny Novgorod, Russia
5 Russian Association of Ozone Therapy, Jordan

Abstract

We observed 55 women which received adjuvant chemotherapy after non-radical surgery for ovary cancer, 35 of them underwent ozone therapy in the form of rectal insufflations of an ozone-oxygen mixture with assistance of the equipments and accessories of Medozons-Company according to a specially developed method.
The present investigation resulted in the following:
–     ozone therapy caused an improvement in patients’ state, in their sleep and appetite, a decrease in nausea and vomiting;
–     ozone therapy produced an immunomodulating effect, mainly on the humoral immunity;
–     ozone therapy improved the indices of lipid peroxidation without exogenous antioxidants.

Based on the above mentioned, we can draw a preliminary conclusion about the clinical efficiency and pathogenetic verification of ozone therapy in the correction of complications associated by chemotherapy of ovarian cancer.

Introduction

Systemic non-specific side effects of chemotherapeutics are frequently considered a limiting factor of further treatment and their efficient correction is the most important measure which is equal in its importance to determination of an adequate course of cytostatic treatment. In order to prevent chemotherapy complications it is necessary to carry out a complex of therapeutic measures of different action, in particular, metabolic treatment with medicines containing antidiabetic biguanides, hypolipidemics, deagregants, adaptogens, anticoagulants, bio protectants,  antioxidants (3).  This  method  has  some  disadvantages,  most  of  all – polypragmasy, which is doubly dangerous on the background of strong cytostatics used. (1).

In this regard, our attention should be drawn to non-medicinal methods of treatment which show high efficiency and cause minimum side effects. As the most promising we consider the use of numerous therapeutical, incl. immunomodulating properties of medical ozone (2,4,5) i.e. a strictly dosed gas mixture of purest ozone and purest medical oxygen.

The aim of an investigation is to study the efficiency of ozone therapy in the correction of complications associated by chemotherapy of ovarian cancer and to verify it pathogenetically.

Read full document on medical ozone ovarian cancer here.

Share Button
More

Ozone Inactivation Kinetics

Ozone inactivation kinetics

Ozone Inactivation Kinetics

Ozone Inactivation Kinetics of Multiple Antibiotic Resistant Strains of Bacteria in Water.

 S. Gutiérrez, I. Lezcano, Ch. Baluja and E. Sánchez  Centro de Investigaciones del Ozono
Calle 230 # 1313 y Avenida 15, Sioney, Playa, Apartado 6412 Ciudad Habana, Cuba.

Received for review:
Accepted for publication:

Abstract

To determine the ozone inactivation kinetic of different Gram positive and Gram negative multiple antibiotics resistant bacterial strains from clinical isolation (CI), that resists too high concentration of chlorine, and compare them with reference strains was our  objective.  Microorganism’s  concentration  was  from 105  to 106  ufc/mL,  and chlorine and ozone concentrations were between 0.5 – 4 mg/L, and 0.36 – 2 mg/L respectively. Gram-positive multiple antibiotic resistant strains are the most resistant bacteria with chlorine. With ozone the multiple antibiotics resistant strains were more resistant that reference strains. There were not statistical differences on ozone resistant inside of strains of same species, neither between Gram positive and Gram negatives multiple antibiotic resistant strains, and for Escherichia coli the resistance not dipped of plasmid witnesses.

Introduction

Of all environmental agents to which we are exposed, water is one of the most important being essential to life, and it is too the more commune infection way (De Marini et al., 1995). The oxidant property of ozone is used in water treatment as a strong germicidal agent (Lee et al., 1991; Laddie and Bland, 1990; Finch and Fatrbaim, 1991).

One of the most important problems in antibiotic therapy is the capability of bacteria to develop multiple antibiotic resistance. A problem of primary concern to public health to the presence of antibiotic resistant bacteria in water, is that they are eliminated by man and animal which eventually pollute water resources, swimming pools, etc. (El- Zanfaly, 1997). Chlorine treatment is the most commonly used method for controlling microorganisms, however chlorine and ultraviolet radiation have been reported to select for antibiotic resistant indicator microorganisms (Finch and Smith, 1987).

The objective of this work is to determine the ozone inactivation kinetics in water of different  Gram  positive  and  Gram  negative  multiple  antibiotic  resistant  bacterial strains from clinical isolation, that resist high concentration of chlorine and compare them with reference strains.

Read full document ozone inactivation kinetics here.

Share Button
More

Ozone Therapy Asthma

Ozone therapy asthma

Ozone Therapy Asthma

Changes in Glutathione Antioxidant Pathway Components, HLA-DR and IgE in Blood from Asthma Patients Treated with Ozone Therapy.

 Frank Hernández, Idania Alvarez, Ivonne Corcho and Maritza González
Department of Biomedicine, Ozone Research Center, National Center for Scientific
Research, A.Postal 6412, Ciudad de La Habana, Cuba.

Abstract

We have studied the behavior of the erythrocyte glutathione antioxidant pathway, the HLA-DR molecule expression and the serum IgE level in patients suffering reactive asthma, whose were treated with ozone major autohemotherapy or rectal insufflation. A subgroup of patients having high levels of serum IgE (> 250 IU/mL) presented high level of HLA-DR expression (> 35 %) and lower concentrations of erythrocyte GSH (<2.00 µmol/g.Hb) and GPx (< 11.62 IU/g.Hb) as a basal state before the beginning of ozone therapy. GST and GR were in the normal range. After to complete 15 sessions of ozone autohemotherapy applications (dose of 8 mg each session), all parameters in the glutathione antioxidant pathway were highly elevated and, IgE and HLA-DR levels decreased markedly respect to the initial values.

With ozone rectal insufflation (20 sessions at an ozone dose of 10 mg each one), similar results were achieved although the changes were not so significant as in authohemotherapy. When the analysis was done considering all patients (with or without initial high level of IgE) the changes in GSH, GPx and GST were sligthly higher after autohemotherapy without changes in GR and IgE, but HLA-DR expression significantly decreased. These findings support a role for IgE producing oxidative stress and inflammation in allergenic asthma. On the other hand, ozone therapy proved to be effective in this disease due, likely, to its regulation on glutathione antioxidant pathway which lead to a control in the oxidative stress present in the asthma patients and a change in the cytokine pattern.

Read the full document ozone therapy asthma here.

Share Button
More