Ozone Therapy Burn Disease
Methodology of using Ozone in the Complex Treatment of Burn Disease at Early Stage
Sergey P. Peretyagin, Olga V. Kostina, Andrey A. Strutchkov, Sergey A. Vilkov,
Artem L. Borisevitch, Dmitriy G. Dmitriev, Vagap A. Shichragimov
Russian Association of Ozonetherapy, Research Institute of Traumatology and Orthopedics,
N.-Volshskaya Naberezhnaya 18, 603155 Nizhny Novgorod, Russia
Pathogenesis of burn disease includes the disturbances of free-radical oxidation (FRO) processes. The method of bio chemiluminescence was used in 55 burn patients (burn area over 20% of body surface, depth – II-IV degree) in order to determine the intensity of lipid peroxidation (LPO), antioxidant activity (AOA), erythrocyte peroxide resistance (EPR) and production of active oxygen species (AOS) in “respiratory explosion” of phagocytes.
Preliminary individual selection of ozone concentration allowed us to carry out a more correct struggle against the disturbances of pro- and antioxidant systems in seriously burned patients.
Administration of active oxygen species (ozone therapy) intensified AOA (by 20-35%), normalized LPO, EPR and activity of phagocytosis. Thus, for correction of free-radical oxidation processes in burn patients ozone therapy should be used associated with monitoring of its efficiency by means of bio chemiluminescence methods.More