Ozone Therapy Fetus Infection
Application of Ozone in Prevention and Treatment of Intrauterine Fetus Infection
Tatiana S.Kachalina, Nadezhda Yu. Katkova, Gennady O. Gretchkanev
Department of Obstetrics and Gynecology, Nizhni Novgorod State Medical Academy,
10/1 Minin sq., N. Novgorod, 603005, Russia
105 pregnant women of a risk group with intrauterine fetus infection and newborns were examined. According to laboratory findings (levels of lipid peroxidation (LP) and antioxidant defense system (AODS), immune status, infectious agents in amniotic liquids, phagocytosis activation) the patients were divided into 2 groups, the 1St group comprising 60 intrauterine infection carriers without inflammatory signs and the 2d group of 45 patients showing the signs of the inflammatory process. Each group was subdivided into the trial group treated with ozone and control one with conventional methods of treatment. The patients received ozonated saline infusions intravenously for 3-5 days, ozone concentration – 800mcg/l. The study demonstrated maximal therapeutic effect in patients of the 1St group (the normalization of LP and AOS indices ( 72%), improvement of immune indices (42%).78% of women with disturbances of uteroplacental blood flow showed a tendency to correction in doppler metric indices. No cases of infectious agent transiting into a fetus were registered in the 1St group. The described effects were not revealed in the 2“d group Ozone was found to have its maximal effect in cases of TORCH infection agents being present without the signs of inflammatory process activation, thus, lessening the percentage of intrauterine fetus infection.
The latest decade showed an increasing interest to the role of infectious agents in the intrauterine fetus lesion. According to Russian authors the incidence of intrauterine infection (IUI) resulting in perinatal mortality ranges from 10% to 37.5%(1,2). The mechanism of IUI development is known to be a complicated one and to evoke multiple debates concerning the questions of infection transition into the infectious process. Subclinical or latent course makes this pathology difficult to diagnose and in cases of pregnancy limits the range of medications necessary for the treatment (3,4,5). It gives rise to a search for new methods to enhance the therapeutic efficacy for this pathological condition.More