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Ozone Therapy Mandible

Ozone therapy mandible

Ozone Therapy Mandible

The Effect of Ozone on   the Lipid Peroxidation Processes in Case of Mandible Fractures.

N.E. Homutinnikova1,  E.A. Durnovo2
1,2Nizhny Novgorod State Medical Academy,  Department of  Surgical Dentistry
and Maxillofacial Surgery, Minin sg. 10/1, 603005, Nizhny Novgorod, RUSSIA.


For  optimizing  osteogenesis  and  preventing  development  of  post-traumatic inflammatory complications of open fractures of mandible we have included ozone therapy in the medical treatment complex. Ozone was administered in 0,9% NaCl solution intravenously and locally as ozonized water. We have performed the comparative analysis of lipid peroxidation indexes and antioxidant activity of blood serum and oral fluid in patients with open fractures of mandible who received conventional treatment and ozone therapy.

The recommended therapy method let us perfect the conventional conservative treatment  of  open  mandibular  fractures  and  prevent  the  development  of posttraumatic inflammatory complications.


The treatment and prophylactics of inflammatory complications of open fractures of mandible is an actual problem in maxillofacial traumatology. Up to  40% of patients suffer from inflammatory complications developed after fractures due to their late visits to an in-patient department. At present, the following    number of factors is found to effect on healing processes of mandible   fractures in an unfavourable way: regional circulation impairment, inflammatory processes and tissue hypoxia at the site of    fracture, oral local immunity inhibition. The localization of a fracture line within denture limits leads to the infection caused  by pathogenic microflora of an oral cavity [1]. It  results in the changes in normal free radical processes on cell membranes. The changes in local defense factors and intensity of lipid peroxidation (LP) processes as well as in antioxidant activity (AOA) of oral fluid are also noticed. Thus, the study of aforementioned indexes is of great interest as for a prognosis of inflammatory complications  , developed in the early posttraumatic period in case of mandible fractures.

Ozone therapy was applied in the complex treatment to optimize osteogenesis and to prevent inflammatory complications of open fractures of mandible.  Ozone is widely applied  in medicine due to the wide spectrum of its biological effects. Among them we should mark its analgesic,  anti inflammatory,  antimicrobial,  trophic  and  immunomodulatory  effects.  The experimental and clinical trials demonstrated that application of ozone at concentration, established by us, produces a positive effect on the level of oxidation-reduction processes in blood, including the increase in its antioxidant  potential [2,3].

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