All posts in Ozone Therapy and Retinitis Pigmentosa

Ozone Therapy Retinitis Pigmentosa

Ozone Therapy Retinitis Pigmentosa

Ozone Therapy Retinitis Pigmentosa

Ozone Therapy in Patients with Retinitis Pigmentosa

 Mirtha Copello1, Frank Eguía2, Silvia Menéndez*3, Niusdalys Menéndez1
 1 Retinitis Pigmentosa National Reference Center. “Dr. Salvador Allende” Hospital. Calzada
del Cerro Ave. and Domínguez, Cerro, Havana, Cuba
2 ” Ramón Pando Ferrer” Ophthalmologic Hospital. 76 St. and 31 Ave. Marianao, Havana, Cuba
3 Ozone Research Center. POBox 6880, Havana. Cuba


Retinitis pigmentosa (RP) is characterized by progressive night blindness. The aim of this study is to determine the efficacy of ozone therapy retinitis pigmentosa. A controlled, randomized, double blind clinical trial involving 68 patients was performed. Patients were divided into 2 groups: ozone, patients were treated with ozone by rectal administration  (dose=10 mg), during  15 sessions; control, as ozone group, but using oxygen. The main outcome variable was the visual field area (VFA). Results demonstrated a significant improvement (SI) in 88.2 % of patients treated with ozone in comparison with 23.5 % achieved in the control group. In the ozone group, VFA tend to stabilize beyond a mean time of 6.83 months with a loose in SI afterward. A temporal positive effect of ozone therapy, over the natural course of RP, was found. It could be useful to apply ozone therapy in the first stages of the disease and at six-month intervals in order to enhance visual capabilities in RP patients.


Retinitis Pigmentosa (RP) is the name usually applied to a diverse group of hereditary retinal degeneration, with an overall prevalence of about 1/4000 (1) and about 1 500 000 affected people  worldwide.  Inheritance  could  be  autosomal  dominant,  recessive,  sex  linked, mitochondrial, digenic or frequently isolated cases are presented. Patients complain of night blindness and  progressive  reduction  of  peripheral  vision (visual  field  loss)  with  a  ring scotoma, with late involvement of central vision and abnormal electroretinogram (2,3). About 50 % of patients with RP are legally blind at middle age, most of them as a result of visual field reduction (4).

Read full document ozone therapy retinitis pigmentosa here.

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