All posts in Ozone Therapy Effects in the Oxidative Stress Associated to Diabetes Mellitus

Ozone Therapy Oxidative Stress

Ozone Therapy Oxidative Stress

Ozone Therapy Oxidative Stress

Ozone Therapy Effects in the Oxidative Stress Associated to Diabetes Mellitus

Saied M. Al-Dalien1, Silvia Menéndez2, Gregorio Martínez1, José I. Fernández-Montequín3,
Eduardo J. Candelario1 and Olga S. León1*

1Center for Research and Biological Evaluation, University of Havana, Institute of Pharmacy
and Food Sciences. Apartado Postal 6079, Havana City 10600, Cuba

2 Ozone Research Center, National Center for Scientific Research. Apartado Postal 6880,
Havana City, Cuba

3 Institute of Angiology and Vascular Surgery. Calzada del Cerro 1551 Cerro. Havana City,


It is well recognized the presence of oxidative stress in diabetes mellitus. Ozone can exert its protective effects by means of an oxidative preconditioning, stimulating and/or preserving the endogenous antioxidant systems. The aim of this paper is to evaluate the ozone effects, in a preclinical and preliminary clinical studies, in the oxidative stress associated to diabetes. Rats were divided in:
1- negative control group;
2- positive, using streptozotocin (STZ) as a diabetes inductor;
3- ozone, 10 treatments (1 mg kg-1), after STZ-induced diabetes and
4- oxygen (26 mg kg-1), as group 3 but using oxygen. Patients with diabetic foot were divided in 2 groups: ozone (using rectal and local ozone) and antibiotic (systemic and locally). Ozone treatment improved glycemic control and prevented oxidative stress associated to diabetes mellitus and its complications, in both studies, in agreement with the excellent results obtained clinically.


Diabetes mellitus is characterized by metabolic abnormalities, a disorder of carbohydrate metabolism, with the presence of hyperglycemia and glycosuria, resulting from inadequate production  or  utilization  of  insulin.  Long-term  complications,  that  cause  morbidity  and premature  mortality,  is  characterized  by  microvascular  disease  with  capillary  basement membrane thickening, macrovascular disease with accelerated atherosclerosis, neuropathy involving both the somatic and autonomic nervous systems, neuromuscular dysfunction with muscle  wasting,  embryopathy  and  decrease  resistance  to  infections.  Such  chronic complications  involve  the  eyes,  kidneys,  heart,  nerves  and  blood  vessels.  Accelerated atherosclerosis produces 80 % of all diabetic mortality, three fourths off it owing to coronary disease. A more frequent concomitant of distal anesthesia is the development of neurotrophic ulceration, particularly on the plantar aspect of the foot. Anesthesia leads to a worsening of any minor injury because of the absence of protective painful stimuli. This problem in addition to pre-existing microvascular and macrovascular circulatory impairments characterizes the underlying mechanisms that may lead to rapid gangrene after foot injury (1,2).

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