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Medical Ozone Threatened Abortion

Medical Ozone Threatened Abortion

Medical Ozone Threatened Abortion

The Experimental Grounds for Safe and Effective Dosage
     of Medical Ozone used in the Treatment of Abortion

Guennadi O. Gretchkanev1, Claudia N. Kontorchikova2, Tatyana S. Katchalina3, El-Hassoun Husein4
1,3 Department of Obstetrics and Gynecology, Medical Academy of Nizhny Novgorod,
Pl. Minina 10/1, 603005 Nizhny Novgorod, Russia
2 Central Research Laboratory, Medical Academy of Nizhny Novgorod,
Pl. Minina 10/1, 603005 Nizhny Novgorod, Russia
4 Russian Association of Ozone Therapy, Jordan


Blood samples of 15 patients with threatened abortion, 15 healthy non-pregnant women  and  15  pregnant  women  without  pathology  were  investigated.  The following indices were determined: the antioxidative plasma activity (by method of  bio chemiluminescence),  the  level  of  diene  conjugates (by  method  of spectrophotometry) and the Schiff’s bases (after D.I.Flether).

The influence of ozone on the above indices depended on the used concentration of ozone. The ozone concentration of 400 mcg/L induced a significant increase (by 2,6 times) in the antioxidative plasma activity. Meanwhile, the level of lipid peroxidation  molecular  products  had  a  tendency  to  decrease.  Higher  ozone concentrations (800 to 1200 mcg/L) led to reverse processes.


For over 100 years ozone has been successfully used in various fields of medicine, but till 1993 in literature there were no references to ozone applications in the treatment of obstetric complications, that was why for safe clinical applications of medical ozone there was a need for experimental grounds of the present method of treatment. The aim of our investigation was to establish in vitro a range of ozone concentrations being safe for the homeostasis of patients with threatened abortion for the purpose of its further using in clinical conditions.

Materials and Methods

As a criterium in vitro for safety and efficiency of the given ozone concentrations it was considered intensification of the antioxidative defense system (AODS) and a decrease in the molecular products of lipid peroxidation (LP). The choice was based on the objectivity and informativity of the above indices as well as their importance for prognosis of obstetric pathologies including threatened abortion (2,3,5,6).

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