Simple Access Fluid Extraction
(Approved by the FDA)
Simple Access Fluid Extraction or S.A.F.E. is a device-based therapy intended to remove extra fluid from blood and body ; Simple Access Fluid Extraction (SAFE) as the name implies. Patients with heart failure typically are treated with various medications, including angiotensin-converting enzyme inhibitors, beta-blockers, diuretics, and inotropic drugs. Although these drugs don’t stop disease progression, they may reduce symptoms and improve functional capacity. Over time, however, some patients stop responding to these therapies.
SAFE, a process that removes fluid from the intravascular compartment, can help ease symptoms for these patients. It may even help patients respond again to conventional drug therapy.
During SAFE, the patient intravascular fluid remains stable, as fluid shifts from extravascular space that is lost from the vessels. This reduces edema and third spacing. But because fluid is not removed from the vascular compartment any faster than it can be recruited from the peripheral tissues, patients do not become hypotensive, the plasma refilling rate is adequate to prevent hypovolemia. The patient’s heart rate, blood pressure and serum electrolytes also remain largely unchanged.
In general, SAFE improves the quality of life with the ceasing of anginal pain and increase of functional abilities. We are proud to say that SAFE is a truly high quality Malaysian invention by a team of medical experts and engineers.
We would also like to dedicate our sincere appreciation to the 1998 Nobel Prize Winners in Physiology or Medicine for their discoveries concerning nitric oxide as a signaling molecules in the cardiovascular system- Robert F. Furchgott (SUNY Health Science Center Brooklyn, New York, USA), Louis J. Ignarro (University of California School of Medicine) and Ferid Murad (University of Texas) for their discoveries concerning the role of nitric oxide as a signaling molecule in the cardiovascular system. These medical experts have given us the inspiration and encouragement to come up with our invention SAFE.
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