Ozone Therapy Mandible
The Effect of Ozone on the Lipid Peroxidation Processes in Case of Mandible Fractures.
N.E. Homutinnikova1, E.A. Durnovo2
1,2Nizhny Novgorod State Medical Academy, Department of Surgical Dentistry
and Maxillofacial Surgery, Minin sg. 10/1, 603005, Nizhny Novgorod, RUSSIA.
For optimizing osteogenesis and preventing development of post-traumatic inflammatory complications of open fractures of mandible we have included ozone therapy in the medical treatment complex. Ozone was administered in 0,9% NaCl solution intravenously and locally as ozonized water. We have performed the comparative analysis of lipid peroxidation indexes and antioxidant activity of blood serum and oral fluid in patients with open fractures of mandible who received conventional treatment and ozone therapy.
The recommended therapy method let us perfect the conventional conservative treatment of open mandibular fractures and prevent the development of posttraumatic inflammatory complications.
The treatment and prophylactics of inflammatory complications of open fractures of mandible is an actual problem in maxillofacial traumatology. Up to 40% of patients suffer from inflammatory complications developed after fractures due to their late visits to an in-patient department. At present, the following number of factors is found to effect on healing processes of mandible fractures in an unfavourable way: regional circulation impairment, inflammatory processes and tissue hypoxia at the site of fracture, oral local immunity inhibition. The localization of a fracture line within denture limits leads to the infection caused by pathogenic microflora of an oral cavity . It results in the changes in normal free radical processes on cell membranes. The changes in local defense factors and intensity of lipid peroxidation (LP) processes as well as in antioxidant activity (AOA) of oral fluid are also noticed. Thus, the study of aforementioned indexes is of great interest as for a prognosis of inflammatory complications , developed in the early posttraumatic period in case of mandible fractures.
Ozone therapy was applied in the complex treatment to optimize osteogenesis and to prevent inflammatory complications of open fractures of mandible. Ozone is widely applied in medicine due to the wide spectrum of its biological effects. Among them we should mark its analgesic, anti inflammatory, antimicrobial, trophic and immunomodulatory effects. The experimental and clinical trials demonstrated that application of ozone at concentration, established by us, produces a positive effect on the level of oxidation-reduction processes in blood, including the increase in its antioxidant potential [2,3].
Ozone Therapy Threatened Abortion
Ozone therapy as the Main Component of the Complex Treatment of Threatened Abortion
Guennadi O. Gretchkanev
Department of Obstetrics and Gynecology, Medical Academy of Nizhny Novgorod,
Pl. Minina 10/1, 603005 Nizhny Novgorod, Russia
Abstract Ozone Therapy Threatened Abortion
80 pregnant women with threatened abortion of infectious (40) and endocrine (40) genesis were treated with medical ozone. We established the following laboratory changes:
– The study of lipid peroxidation processes on the background of ozone therapy showed a decrease in the primary and secondary molecular products. The average 22,1% increase in the total antioxidative plasma activity was established.
– The patients treated with ozone showed an average week’s increase in progesterone concentration 3,3 times higher, in placental lactogen 2,4-3,6 times higher as compared with the conventional treatment.
– After using ozone therapy, we established a credible decrease (by 20-50%) in circulating immune complexes. That correlated with intensification of the phagocytic activity. The level of IgM had a tendency to normalize.
Thus, owing to its varied positive effects on pregnant women ozone therapy has proved to be an effective method of treatment and prophylaxis of threatened abortion.
The problem of threatened abortion being of great medical as well as social importance remains one of the most topical in obstetrics and gynecology. In reference to Russian author’s, frequency of this pathology is 10-25% (4,5). There are 40-80% of premature neonates in the structure of perinatal mortality (1), among them there are 50% of deadborn, 60-70% cases of neonatal mortality and 67-75% cases of infant mortality (2). In reference to the above data, there is an urgent need for new, probably not-traditional therapeutical approaches to this medical problem.
The use of ozone in the medicine has been known for over 100 years, in that period the most important aspects of action of this gas on human body were established – its disinfection activity, its ability to stimulate the circulation, to stabilize the state of cell membranes and so on. Medical ozone has been widely used in surgery, various specialities of internal medicine, intensive care, dermatology and other medical fields, but till now there have been only isolated reports about ozone applications in the treatment of gynecological pathologies
Ozone Therapy Fetus Infection
Application of Ozone in Prevention and Treatment of Intrauterine Fetus Infection
Tatiana S.Kachalina, Nadezhda Yu. Katkova, Gennady O. Gretchkanev
Department of Obstetrics and Gynecology, Nizhni Novgorod State Medical Academy,
10/1 Minin sq., N. Novgorod, 603005, Russia
105 pregnant women of a risk group with intrauterine fetus infection and newborns were examined. According to laboratory findings (levels of lipid peroxidation (LP) and antioxidant defense system (AODS), immune status, infectious agents in amniotic liquids, phagocytosis activation) the patients were divided into 2 groups, the 1St group comprising 60 intrauterine infection carriers without inflammatory signs and the 2d group of 45 patients showing the signs of the inflammatory process. Each group was subdivided into the trial group treated with ozone and control one with conventional methods of treatment. The patients received ozonated saline infusions intravenously for 3-5 days, ozone concentration – 800mcg/l. The study demonstrated maximal therapeutic effect in patients of the 1St group (the normalization of LP and AOS indices ( 72%), improvement of immune indices (42%).78% of women with disturbances of uteroplacental blood flow showed a tendency to correction in doppler metric indices. No cases of infectious agent transiting into a fetus were registered in the 1St group. The described effects were not revealed in the 2“d group Ozone was found to have its maximal effect in cases of TORCH infection agents being present without the signs of inflammatory process activation, thus, lessening the percentage of intrauterine fetus infection.
The latest decade showed an increasing interest to the role of infectious agents in the intrauterine fetus lesion. According to Russian authors the incidence of intrauterine infection (IUI) resulting in perinatal mortality ranges from 10% to 37.5%(1,2). The mechanism of IUI development is known to be a complicated one and to evoke multiple debates concerning the questions of infection transition into the infectious process. Subclinical or latent course makes this pathology difficult to diagnose and in cases of pregnancy limits the range of medications necessary for the treatment (3,4,5). It gives rise to a search for new methods to enhance the therapeutic efficacy for this pathological condition.
Ozone Therapy Postherpetic Neuralgia
OZONE THERAPY FOR POSTHERPETIC NEURALGIA
A retrospective study of 55 cases
Heinz Konrad, M.D.
Largo Como 330, 04922-130 São Paulo, Brazil
This study evaluates the outcome of ozone therapy given to 55 patients suffering from post-herpetic neuralgia, for whom “conventional” therapies brought no relief. The author makes several considerations regarding the assessment of pain, the details of ozone therapy, the coadjuvant medication, and the criteria for the evaluation of the results, i.e. the reduction or elimination of pain. From the statistical data the author concludes that ozone therapy is an effective therapeutic approach for post-herpetic neuralgia, especially when all other so-called “conventional” methods have failed.
Postherpetic neuralgia ( PHN ) is one of the most challenging types of pain one can be confronted with. The results of “conventional” therapy are normally rather poor. About 20% of Herpes zoster patients can be expected to develop PHN. This percentage will be higher for patients who are older, and/or diabetic, and/or immune-deficient. Patients normally have great difficulty to understand the fact that such pain can exist even after the skin lesions have long disappeared. Also, as successive therapeutic approaches result in no alleviation of their pain, patients become more and more restive, more and more incredulous about any new approach, hopeless, and often resigned.
As to the pathogenesis of Herpes zoster, the presently prevailing theory is the reactivation of Varicella-Zoster viral units, which had remained incubated and inert in sensitive spinal
ganglion(s) or Trigeminal ganglion(s) ever since the patient’s Varicella disease during childhood.
Presently, there seems to be at least one consensus : the earlier the intensive treatment of Herpes zoster is started, with whatever therapeutical method, the greater the chance of avoiding or at least minimizing the PHN. Also, it seems that the following facts lead to expect a more severe PHN : stronger pain during the prodromic phase of Herpes zoster, stronger pain during the acute phase of H. zoster, more severe cutaneous lesions during H. zoster, and sensitive deficit within the affected dermatome already during the acute phase of zoster.