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Medical Ozone Threatened Abortion

Medical Ozone Threatened Abortion

Medical Ozone Threatened Abortion

The Experimental Grounds for Safe and Effective Dosage
     of Medical Ozone used in the Treatment of Abortion

Guennadi O. Gretchkanev1, Claudia N. Kontorchikova2, Tatyana S. Katchalina3, El-Hassoun Husein4
1,3 Department of Obstetrics and Gynecology, Medical Academy of Nizhny Novgorod,
Pl. Minina 10/1, 603005 Nizhny Novgorod, Russia
2 Central Research Laboratory, Medical Academy of Nizhny Novgorod,
Pl. Minina 10/1, 603005 Nizhny Novgorod, Russia
4 Russian Association of Ozone Therapy, Jordan

 Abstract

Blood samples of 15 patients with threatened abortion, 15 healthy non-pregnant women  and  15  pregnant  women  without  pathology  were  investigated.  The following indices were determined: the antioxidative plasma activity (by method of  bio chemiluminescence),  the  level  of  diene  conjugates (by  method  of spectrophotometry) and the Schiff’s bases (after D.I.Flether).

The influence of ozone on the above indices depended on the used concentration of ozone. The ozone concentration of 400 mcg/L induced a significant increase (by 2,6 times) in the antioxidative plasma activity. Meanwhile, the level of lipid peroxidation  molecular  products  had  a  tendency  to  decrease.  Higher  ozone concentrations (800 to 1200 mcg/L) led to reverse processes.

Introduction

For over 100 years ozone has been successfully used in various fields of medicine, but till 1993 in literature there were no references to ozone applications in the treatment of obstetric complications, that was why for safe clinical applications of medical ozone there was a need for experimental grounds of the present method of treatment. The aim of our investigation was to establish in vitro a range of ozone concentrations being safe for the homeostasis of patients with threatened abortion for the purpose of its further using in clinical conditions.

Materials and Methods

As a criterium in vitro for safety and efficiency of the given ozone concentrations it was considered intensification of the antioxidative defense system (AODS) and a decrease in the molecular products of lipid peroxidation (LP). The choice was based on the objectivity and informativity of the above indices as well as their importance for prognosis of obstetric pathologies including threatened abortion (2,3,5,6).

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Ozone Therapy Threatened Abortion

Ozone therapy threatened abortion

Ozone Therapy Threatened Abortion

Ozone therapy as the Main Component of the Complex Treatment of Threatened Abortion

Guennadi O. Gretchkanev
Department of Obstetrics and Gynecology, Medical Academy of Nizhny Novgorod,
Pl. Minina 10/1, 603005 Nizhny Novgorod, Russia

Abstract Ozone Therapy Threatened Abortion

80 pregnant women with threatened abortion of infectious (40) and endocrine (40) genesis were treated with medical ozone. We established the following laboratory changes:

–     The study of lipid peroxidation processes on the background of ozone therapy showed a decrease in the primary and secondary molecular products. The average   22,1%  increase  in  the  total  antioxidative  plasma  activity  was established.
–     The  patients  treated  with  ozone  showed  an  average  week’s  increase  in  progesterone concentration  3,3 times higher, in placental lactogen  2,4-3,6  times higher as compared with the conventional treatment.
–     After using ozone therapy, we established a credible decrease (by 20-50%) in circulating immune complexes. That correlated with intensification of the phagocytic activity. The level of IgM had a tendency to normalize.
Thus, owing to its varied positive effects on pregnant women ozone therapy has proved to be an effective method of treatment and prophylaxis of threatened abortion.

Introduction

The problem of threatened abortion being of great medical as well as social importance remains one of the most topical in obstetrics and gynecology. In reference to Russian author’s, frequency of this pathology is 10-25% (4,5). There are 40-80% of premature neonates in the structure of perinatal mortality (1), among them there are 50% of deadborn, 60-70% cases of neonatal mortality and 67-75% cases of infant mortality (2). In reference to the above data, there is an urgent need for new, probably not-traditional therapeutical approaches to this medical problem.

The use of ozone in the medicine has been known for over 100 years, in that period the most important aspects of action of this gas on human body were established – its disinfection activity, its ability to stimulate the circulation, to stabilize the state of cell membranes and so on. Medical ozone has been widely used in surgery, various specialities of internal medicine, intensive care, dermatology and other medical fields, but till now there have been only isolated reports about ozone applications in the treatment of gynecological pathologies

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